What is L-Methylfolate

Folate, otherwise known as vitamin B9, is one of the 13 essential vitamins. Vitamins come in different forms called vitamers that often need to be converted in the body to active forms of the vitamin. The active form of folatein the body is L-methylfolate, also known as levomefolic acid, which can cross both cell membranes and the blood-brain barrier [R].

A critical role of L-methylfolate is to act as a regulator of a class of neurotransmitters called monoamines. The three different neurotransmitters it helps make are [R]:

Serotonin
Dopamine
Norepinephrine
*Folate can’t be synthesized by the body, so it must be ingested either through food or supplements [R].

Get 20% off  L-Methylfolate Supplements.

The synthetic form of folate is folic acid, which can be found in fortified foods such as bread and cereals, and multivitamins [R, R].

Dihydrofolate is the dietary form of folate and can be found in green vegetables, egg yolk, legumes, grains, nuts, some fruits, yeast, and organ meats like liver and kidneys [R, R].

Both folic acid and dihydrofolate are converted into L-methylfolate in the body by a specific enzyme. It is then transported into the brain where it increases the production of the three neurotransmitters mentioned above [R].

Folic acid supplementation and unmetabolized folic acid have been associated with increased incidence of prostate cancer, lower cognitive test scores, and smaller red blood cells [R, R].

Methylfolate is responsible for many methylation reactions all throughout the body. Methylation reactions occur when methylfolate donates a methyl group (three hydrogens bonded to one carbon atom) to another molecule [R].

Methylation reactions are crucial for processes such as cell division and DNA and RNA synthesis. Methylation of DNA and RNA plays a crucial role in epigenetics, which is a change in gene activity without changes to the underlying genetics [R].

Although many people take L-methylfolate supplements, much of the naturally ingested L-methylfolate actually comes in the form of different folates such as folic acid and dihydrofolate [R,R].

The conversion of these folates to L-methylfolate is crucial because L-methylfolate can cross the blood-brain barrier, while the other forms of folate can’t [R].

L-methylfolate is commonly used to slow cognitive decline that is seen in many mental disorders, including Alzheimer’s, mania, and depression. Many of these disorders are linked to mutations in the gene that produce the enzyme that converts folate into L-methylfolate,  5, 10-methylenetetrahydrofolate (MTHFR) [R, R, R, R].

Mutations in MTHFR can lead to decreased methylfolate production. Mutations in MTHFR are very common and there are up to 30 different kinds of MTHFR mutation variations [R]………….

Important Information From Scott Wajcman, Your Alfasigma USA, Inc. Representative
Not Everyone Can Fully Metabolize Folate
Folate plays a role in neurotransmitter production1
Dear Dr Eveillard:
A majority of patients with major depressive disorder (MDD) may not be able to fully metabolize folate into its active form due to a methylenetetrahydrofolate reductase (MTHFR) polymorphism.2 In fact, up to 70% of patients with MDD may have an MTHFR polymorphism, which may compromise the ability to convert folic acid into the active form, L-methylfolate, that helps support monoamine regulation.2,3 MTHFR polymorphisms are associated with a decrease in folate concentrations, which may lead to an increased risk of depressive symptoms.2
When added to antidepressants, L-Methylfolate in can make a difference. Add DEPLIN® capsules for patients who are not fully responding to their antidepressant therapy. DEPLIN® may provide the nutritional requirements the body needs to produce neurotransmitters that help antidepressants to work effectively.1,4-6
Dr Andrew Cutler discusses the unmet need in MDD and how

L-Methylfolate in DEPLIN® can help

Watch Now
When added to an SSRI in patients who are not fully responding to their antidepressant therapy,
L-Methylfolate in DEPLIN® was shown to reduce depressive symptoms by up to 84% in 30 days*7

Folate can’t be synthesized by the body, so it must be ingested either through food or supplements [R].

Get 20% off  L-Methylfolate Supplements.

 Some of my patients and visitors are asking for info about the non-addictive THC free Cannabinoid(CBD) use as alternative medicine for psyh and non psych ailments.  Below are some research articles and references:

*Disclaimer: This video is for info only. We are not affiliated with PMB nor does this constitute endorsement or promotion or their system or products.

CBD may have brain anti-inflammatory, anticonvulsant, antianxiety, antipsychotic, antioxidant, neuroprotective and immunomodulatory effects.

CBD is Safe and Legal Nutritional Product across all fifty states, USA-made, and produced with federally-legal Cannabidiol (CBD).

Does CBD have a role in the Management of Depression?

Feeling depressed is a common part of life. It is a normal coping mechanism of the human organism in the face of loss and disaster. The problem starts when depression lasts for an extended amount of time and/or prevents an individual from being

Depression can manifest as chronic feelings of sadness and loss of motivation in all aspects of the patient’s life. Patients can feel overwhelmed with negative emotions and emptiness for no apparent reason. These major symptoms can lead to a myriad other emotional and physical problems that may have severe repercussions on the patient’s everyday life.

Clinical depression can have unpredictable effects that range from insomnia or sleeping too much, to overeating or not eating enough, to body aches and even heart attacks. Depression is not a condition that someone can simply “snap out of.” It requires proper medical attention.

Often called, clinical depression, major depressive disorder is a highly prevalent illness that can spiral out of control if left untreated. But it can be managed. According to CBD users, cannabidiol has a positive impact on people who suffer from depression.

How many people suffer from depression?

A 2014 CDC report claims that in the period between 2009–2012, 7.6% of Americans aged 12 and over had moderate or severe depressive symptoms. The most prone age group that showed signs of depressive disorder were females and persons aged 40–59.

The report also reveals that 3% of Americans over 12 years old have had severe depressive symptoms and that people living below the poverty level were almost three times more likely to develop depression than those above the poverty line.

Among the people who exhibited severe depressive symptoms, 43% reported serious difficulties in work, personal and social situations. Only 35% actively sought mental health counseling by a professional (which can cost $75-$150 per visit, on average).

Depression rates are higher among females than males in every age group. Another interesting fact that the study reveals is that rates of depression increase with age, before it begins to decline in adults aged 60+.

Specifically, depression rates by age group were: 5.7% among youth aged 12–17 to 9.8% among adults aged 40–59, with adults aged 60 showing a lower rate of depression (5.4%) than those aged 18–39 and 40–59. The highest rate of depression, 12.3%, was found in women aged 40–59, while the lowest rates of depression were for males aged 12–17 (4.0%) and 60 and over (3.4%).

What causes depression?

Scientists at Harvard University, have used advanced brain imaging such as PET scans and fMRI scans in order to get a closer look at the inner workings of the brain. Use of this sophisticated technology has led to a better understanding of the extent that brain imbalances have in the manifestation of depression. The areas of the brain that play a significant role in depression are the amygdala, the thalamus, and the hippocampus.

Depression and Brain Imbalances

Researchers at Harvard are trying to connect the dots between the slow production of neurons in the hippocampus part of the brain and feelings of depression. This theory is further supported by how antidepressants work: specialized medication immediately boosts the number of neurotransmitters in the brain, gradually improving the patient’s mood.

However, if depression was exclusively the result of imbalances of brain chemicals, then people would feel better immediately after they were administered medication.

Depression As a Side Effect

Depression can be triggered by a variety of emotional or physical issues. Severe life changes, grief from the death of a loved one, major illnesses can cause depression. There are also individuals with a family history of depression.

Depression is closely linked with anxiety. Some of the factors that can play a significant role in the appearance of depression in one’s life are:

  • Physical or emotional abuse
  • Medication side-effects
  • Grief caused by death or a loss
  • Genetic predisposition
  • PTSD & Major life events, such as the move to a new city or retirement
  • Serious illness
  • Substance abuse

How is depression diagnosed?

Depression can be diagnosed by a licensed professional, who can determine whether someone suffers from depression through counseling. This requires the patient to be open about their experiences and ready to accurately describe their symptoms. Depressed individuals often feel like they are not sick, or that there is no treatment for their condition.

Although in most cases there are no physical tests for depression, psychiatrists may require some tests in order to rule out conditions like thyroid disease.

How harmful is depression?

Depression can become dangerous if left untreated. 65% of people who suffer from depression in the US do not seek professional help. Untreated depression can cause serious problems in the patient’s everyday life by increasing conflict, causing lethargy, and increasing the chances of drug addiction.

Clinical Depression and Physical Health

There is mounting evidence suggesting that major depression poses risks to a person’s physical health. Studies have been exploring the connection between depression and patients that suffered strokes or heart diseases. The results have shown that recovering individuals who suffer from major depression have a more difficult time making healthcare choices and often fail to follow their doctor’s instructions.

How is depression treated?

The most common treatments for depression are through medication and/or psychotherapy. These two are often used together and yield favorable results. Essentially, psychotherapy reduces negative thought patterns that perpetuate depression, while medicine tries to balance hormonal activity in the brain.

It is highly recommended that people with depression stay physically active, as exercise naturally raises levels of serotonin in the brain. Research has proven that physical activity can be as effective as medicine in regulating symptoms of severe depression.

How does CBD help treat depression?

As studies on the beneficial effects of CBD pile up, it was only a matter of time before the medical community started to research the possibility of using CBD as a cure for depression.

A 2014, a study conducted with animal models proved that CBD has significant antidepressant and anxiolytic properties. Lab mice underwent a number of tests and results have shown that when treated with CBD, the subjects showed fewer instances of depression and anxiety.

There is no conclusive evidence that CBD can have a positive impact on depression, however, studies have shown that use of CBD can indeed impact the levels of serotonin in the body and improve sleeping patterns.

Research on the connection between depression and physical symptoms has proven that depression and pain share a common neurochemical pathway that are both influenced by serotonin and norepinephrine.

Previous research has proven that CBD has antidepressant effects that trigger the release of anandamide, a neurotransmitter responsible for controlling the serotonin levels in the human body.

Studies involving CBD and depression

 

Additional sources of information

Other articles on CBD and depression

Sponsors

The research and talent that went into this article and infographic was made possible by a grant from High Country Group, LLC. Visit High Country’s CBD website for top-quality CBD products.

FDA Disclaimer

The statements in this document have not been evaluated by the Food and Drug Administration and are not intended to be used to diagnose, treat, cure or prevent any disease. Consult your physician before beginning any treatment regimen.

Legal Disclaimer

Information on this site is provided for informational purposes only and is not meant to substitute for the advice provided by your own physician or other medical professional. The results reported the lab studies mentioned in this document may not necessarily occur in all individuals. CBD Wellness Guide makes no representations or warranties of any kind with respect to this site or its content

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    • Sometimes you want other types of resources, including information and message boards. Below is a list of websites and phone numbers for organizations that address many of the topics people talk about online.

Local Information and Referrals Resoueces
Domestic Abuse
Eating Disorders
Gay, Lesbian, Bisexual, and Transgender
Mental Health
Pregnancy & Sexual Health
Non-Suicidal Self Injury
Sexual Abuse/Assault
Suicide
Veterans
Youth/Teens

    • Local Information and Referrals Resources
      211
      211.org
      A website on which you can enter in a ZIP code or city/state combo to be directed to an online referral database in the that area (when available). Can also dial 211.
    • Domestic Abuse
      DomesticViolence.org
      http://www.domesticviolence.org/personalized-safety-plan/
      Site provides a personalized safety plan for anyone in an abusive relationship, along with excellent information and referrals.
    • Love is Respect Chat
      www.loveisrespect.org
      A hotline and chat service for young adults, but no one is turned down. Focus is on abusive vs. healthy relationships. Chat is run by young adult peer advocates.
    • Eating Disorders
      National Eating Disorders Association — Information & Referral Helpline
      800-931-2237
      Informational website: http://www.nationaleatingdisorders.org/
    • Something Fishy Website on Eating Disorders
      http://www.something-fishy.org/
      Dedicated to raising awareness about eating disorders – emphasizing that eating disorders are NOT about food; they are the symptoms of something deeper.
    • Gay, Lesbian, Bisexual, and Transgender
      GLBT National Help Center
      General talkline: 888-843-4564
      Youth talkline: 800-246-PRIDE (7743)
      http://www.volunteerlogin.org/chat/
      A chat service offering one-on-one peer support for gay, lesbian, bisexual, transgender and questioning people, run by the GLBT National Help Center.
      ………Monday through Friday 4pm – Midnight, Eastern
      ………Saturday noon to 5pm, Eastern
    • Trevor Lifeline
      866-488-7386
      Hotline for GLBT youth.
      http://www.thetrevorproject.org/chat
      A chat service for GLBTQ youth.
    • It Gets Better
      http://www.itgetsbetter.org/
      The It Gets Better Project was created to show young LGBT people the happiness and potential their lives will reach once they can get through their teen years.
    • Mental Health Resources
      National Alliance on Mental Illness
      http://www.nami.org/template.cfm?section=your_local_nami
      Find the nearest NAMI chapter by location. Obtain information and advocacy assistance, and take part in local awareness activities.
    • ManTherapy.org
      ManTherapy.org is made for working-aged men who may be dealing with depression or suicide. This innovative site combines excellent information and humor.
    • Mood Gym
      https://moodgym.anu.edu.au/welcome
      Learn cognitive behavior therapy skills for preventing and coping with depression. This interactive website helps users learn healthy behaviors.
    • Healing From BPD
      http://www.my-borderline-personality-disorder.com/
      This blog, list of resources, and chat room were created to share the real world applications of Dialectical Behavior Therapy skills.
    • Boys Town
      1-800-448-3000
      http://www.yourlifeyourvoice.org/Pages/default.aspx
      Boys Town provides a hotline and chat for kids, teens and young adults who are depressed or faced with an overwhelming challenge.
    • To Write Love on Her Arms
      http://www.twloha.com/facts/
      Information on depression, self-injury, addictions and suicide and the relationships between them, and give hope to people dealing with these issues.
    • Pregnancy & Sexual Health
      Planned Parenthood
      http://www.plannedparenthood.org/info-for-teens/pregnancy-33811.asp
      Planned Parenthood chat site where clients can ask questions about pregnancy, STDs, birth control, emergency contraception and abortion and can get referrals.
      Text “PPNOW” to 774636 (PPINFO)
    • Non-Suicidal Self Injury
      Self Abuse Finally Ends (S.A.F.E)
      www.selfinjury.com
      S.A.F.E. is a highly regarded treatment approach for NSSI. The website has information about treatment and links for help in finding a therapist for help with NSSI.
    • To Write Love on Her Arms
      http://www.twloha.com/facts/
      Information on depression, self-injury, addictions and suicide and the relationships between them, and hope for people dealing with these issues.
    • The Butterfly Project
      http://butterfly-project.tumblr.com/
      Special practice for avoiding self-injury by drawing butterflies on yourself (more guidelines on the website).
    • Sexual Abuse/Assault
      Rape, Abuse, Incest National Network Chat
      http://apps.rainn.org/ohl-bridge/
      A chat service for sexual assault survivors, run by RAINN.
    • Suicide
      The National Suicide Prevention Lifeline
      1-800-273-TALK
      suicidepreventionlifeline.org
      The Lifeline is a network of 160 crisis centers in 50 states which provides confidential emotional support to people in suicidal or emotional distress.
    • IMAlive
      https://www.imalive.org/
      IMAlive provides crisis intervention services via online chat. Their services are available on weekdays starting at 7pm Eastern Time and running to 10:30 or 12:30 pm, depending on the day.
    • ReachOut USA
      http://us.reachout.com/
      ReachOut USA uses the internet to provide information teens and young adults need and want in an anonymous, non-threatening and non-judgmental space.
    • To Write Love on Her Arms
      http://www.twloha.com/facts/
      Information on depression, self-injury, addictions and suicide and the relationships between them, and give hope to people dealing with these issues.
    • ManTherapy.org
      ManTherapy.org is made for working-aged men who may be dealing with depression or suicide. This innovative site combines excellent information and humor.
    • Five Alive
      http://fivealive.us/index.html
      Five Alive is dedicated to providing teens and young adults with the information they need to help a friend who may be considering suicide.
    • Veterans
      VA Chat
      http://www.veteranscrisisline.net/ChatTermsOfService.aspx
      A 24/7 chat service for veterans, run by the VA.
    • Youth/Teens Resources
      Boys Town
      1-800-448-3000
      http://www.yourlifeyourvoice.org/Pages/default.aspx
      Boys Town provides a hotline and chat for kids, teens and young adults who are depressed or faced with an overwhelming challenge.
    • Teen Line
      310-855-HOPE (4673)
      800-TLC-TEEN (852-8336) (toll-free in California only)
      Informational website: http://teenlineonline.org/category/help-online/
      Text TEEN LINE by texting “TEEN” to 839863
    • Teens Health
      http://teenshealth.org/teen/
      Tons of info on all kinds of issues that teens face, including depression, bullying, drugs/alcohol, sexual health, etc.
    • Five Alive
      http://fivealive.us/index.html
      Five Alive is dedicated to providing teens and young adults with the information they need to help a friend who may be considering suicide.
    • Love is Respect Chat
      www.loveisrespect.org
      A hotline and chat service for young adults, but no one is turned down. Focus is on abusive vs. healthy relationships. Chat is run by young adult peer advocates.
    • National Runaway Switchboard
      http://www.1800runaway.org/
      For runaway teens or teens considering leaving home.
      ……….4:30pm-11:30pm Central
    • Covenant House Nineline
      1-800-999-9999
      http://nineline.org/
      Hotline: 4:00 p.m. to 8:00 p.m. Eastern Time, seven days a week.
      NINELINE CHAT: Tuesdays and Saturdays from 5:00 p.m. to 7:00 p.m., Eastern Time.
    • Do Something
      http://www.dosomething.org/
      DoSomething.org provides teens with campaigns and causes they can take part in to make the world a better place.
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Other Patients and family resources

 

 

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Antidepressants and Pregnancy: Keeping Risks in Perspective

It‘s important to keep the risks associated with antidepressant use in pregnancy in perspective. All pregnant women have an average 3% risk of having a baby with any type of birth defect in most cases. When researchers say antidepressants may increase the risk of certain birth defects, they are talking about just a slight increase. For example, one study showed that antidepressants increased the risk that the baby would be born with PPHN by 1%. So, even if you take an antidepressant during pregnancy, the overall risk of your baby having a problem is still very low. Other studies showed different levels of risk associated with antidepressants and PPHN, and 1% is on the high end. So the risk may be even lower.

Pregnancy and Antidepressants: Medication Options

Some antidepressants are considered safer for pregnant women than others. Antidepressants that are considered safer include:

But if you are pregnant and taking an antidepressant that is not on this list, do not worry. Even the more controversial ones, including paroxetine (Paxil), have relatively low risk. Changing medications mid-pregnancy poses its own set of problems. Talk to your doctor and see what he or she thinks would be best for you.

If you are not pregnant but planning on becoming pregnant, it may be worth trying a different medication if you are concerned about the safety of your current antidepressant. Again, talk to your doctor to see if this is a good option for you.

Pregnancy and Antidepressants: What to Do?

No matter how small the risk, no mother wants to unnecessarily expose her baby to medicine. Making the decision to take or stop taking antidepressants in pregnancy is not easy. There is no right answer. You must look at your own set of circumstances and make the decision based on the risks and benefits unique to you. If you and your doctor think you may be able to stop your medication during pregnancy, it is certainly worth a try. But, never stop taking your medication without talking to your doctor first. Most antidepressants require weaning to safely stop the drug. If you need to stay on an antidepressant while you are pregnant, don’t panic. Remember, the risks associated with most of the antidepressants in pregnancy are extremely low. Untreated depression could pose a greater risk.

Whatever you finally decide to do, do not second-guess yourself. Once you make the decision, accept it and move on. Trust yourself and your doctors. Like you, your doctors want the very best possible outcome — a healthy mom and baby.

 

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