What is L-Methylfolate: Get 20% off L-Methylfolate Supplements.

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What is L-Methylfolate

Folate, otherwise known as vitamin B9, is one of the 13 essential vitamins. Vitamins come in different forms called vitamers that often need to be converted in the body to active forms of the vitamin. The active form of folatein the body is L-methylfolate, also known as levomefolic acid, which can cross both cell membranes and the blood-brain barrier [R].

A critical role of L-methylfolate is to act as a regulator of a class of neurotransmitters called monoamines. The three different neurotransmitters it helps make are [R]:

Serotonin
Dopamine
Norepinephrine
*Folate can’t be synthesized by the body, so it must be ingested either through food or supplements [R].

Get 20% off L-Methylfolate Supplements.

The synthetic form of folate is folic acid, which can be found in fortified foods such as bread and cereals, and multivitamins [R, R].

Dihydrofolate is the dietary form of folate and can be found in green vegetables, egg yolk, legumes, grains, nuts, some fruits, yeast, and organ meats like liver and kidneys [R, R].

Both folic acid and dihydrofolate are converted into L-methylfolate in the body by a specific enzyme. It is then transported into the brain where it increases the production of the three neurotransmitters mentioned above [R].

Folic acid supplementation and unmetabolized folic acid have been associated with increased incidence of prostate cancer, lower cognitive test scores, and smaller red blood cells [R, R].

Methylfolate is responsible for many methylation reactions all throughout the body. Methylation reactions occur when methylfolate donates a methyl group (three hydrogens bonded to one carbon atom) to another molecule [R].

Methylation reactions are crucial for processes such as cell division and DNA and RNA synthesis. Methylation of DNA and RNA plays a crucial role in epigenetics, which is a change in gene activity without changes to the underlying genetics [R].

Although many people take L-methylfolate supplements, much of the naturally ingested L-methylfolate actually comes in the form of different folates such as folic acid and dihydrofolate [R,R].

The conversion of these folates to L-methylfolate is crucial because L-methylfolate can cross the blood-brain barrier, while the other forms of folate can’t [R].

L-methylfolate is commonly used to slow cognitive decline that is seen in many mental disorders, including Alzheimer’s, mania, and depression. Many of these disorders are linked to mutations in the gene that produce the enzyme that converts folate into L-methylfolate, 5, 10-methylenetetrahydrofolate (MTHFR) [R, R, R, R].

Mutations in MTHFR can lead to decreased methylfolate production. Mutations in MTHFR are very common and there are up to 30 different kinds of MTHFR mutation variations [R]………….

*Folate can’t be synthesized by the body, so it must be ingested either through food or supplements [R].

Get 20% off L-Methylfolate Supplements.